Clemson Canine Genetics

Click here to edit subtitle


2011-2022 Publications

Bell SM, Evans JM, Evans KM, Tsai KL, Noorai RE, Famula TR, Holle DM, Clark LA (2022). Congenital idiopathic megaesophagus in the German shepherd dog is a sex-differentiated trait and is associated with an intronic variable number tandem repeat in Melanin-Concentrating Hormone Receptor 2. PLOS Genetics 18(3):e1010044. [PubMed abstract]

Abrams SR, Hawks AL, Evans JM, Famula TR, Mahaffey M, Johnson GS, Mason JM, Clark LA (2020). Variants in FtsJ RNA 2´-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs. Proceedings of the National Academy of Sciences 117(40): 24929-24935. [PubMed abstract]

Tsai KL, Vernau KM, Winger K, Zwueste DM, Sturges BK, Knipe M, Williams DC, Anderson KJ, Evans JM, Guo LT, Clark LA, Shelton GD (2019). Congenital myasthenic syndrome in Golden Retrievers is associated with a novel COLQ mutation. Journal of Veterinary Internal Medicine 34(1), 258-265. [PubMed abstract]

Tsai KL, Evans JM, Noorai RE, Starr-Moss AN, Clark LA (2019). Novel Y Chromosome Retrocopies in Canids Revealed through a Genome-Wide Association Study for Sex. Genes 10(4): 320. [PubMed abstract]

Murphy SC, Recio A, de la Fuente C, Guo LT, Shelton GD, Clark LA (2019). A glycine transporter SLC6A5 frameshift mutation causes startle disease in Spanish greyhounds. Human Genetics 1-5. [PubMed abstract]

Murphy SC, Evans JM, Tsai KL, Clark LA (2018). Length variations within the Merle retrotransposon of canine PMEL: correlating genotype with phenotype. Mobile DNA 9:26. [PubMed abstract]

Cox ML, Evans JM, Davis AG, Guo LT, Levy JR, Starr-Moss AN, Salmela E, Hytonen MK, Lohi H, Campell KP, Clark LA, Shelton GD (2017). Exome sequencing reveals independent SGCD deletions causing limb girdle muscular dystrophy in Boston terriers. Skeletal Muscle 7:15. [PubMed abstract]

Evans JM, Noorai RE, Tsai KL, Starr-Moss AN, Hill CM, Anderson KJ, Famula TR, Clark LA (2017). Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci. PLoS Genetics 13(3): e1006604. [PubMed abstract]


Evans JM, Cox ML, Huska J, Li F, Gaitero L, Guo LT, Casal ML, Granzier HL, Shelton GD, and Clark LA (2016). Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy. Mammalian Genome 27:495-502.   [PubMed abstract]


Rinz CJ, Lennon VA, James F, Thoreson J, Tsai KL, Starr-Moss AN, Humpries HD, Guo LT, Palmer AC, Clark LA, and Shelton GD (2015). A CHRNE frameshift mutation causes congenital myasthenic syndrome in young Jack Russell terriers. Neuromuscular Disorders 25: 921-927. [PubMed abstract]


Evans JM, Tsai KL, Starr-Moss AN, Steiner JM, and Clark LA (2015). Association of DLA-DQB1 alleles with exocrine pancreatic insufficiency in Pembroke Welsh corgis. Animal Genetics 46: 462-465. [PubMed abstract]


Rinz CJ, Levine J, Minor KM, Humphries HD, Lara R, Starr-Moss AN, Guo LT, Shelton GD, and Clark LA (2014). A COLQ missense mutation in Labrador retrievers having congenital myasthenic syndrome. PLoS ONE 9(8): e106425. [PubMed abstract]


Clark LA and Starr-Moss AN (2013). Genetics and genomics of the domestic dog. In: Molecular and Quantitative Animal Genetics. Ed: H. Khatib. Hoboken, New Jersey. Wiley-Blackwell. (121-130). [Online Text]


Tsai KL, Starr-Moss AN, Venkataraman GM, Robinson C, Kennedy LJ, Steiner JM, and Clark LA (2013). Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics 65: 501-509. [PubMed abstract]


Noorai RE, Freese NH, Wright LM, Chapman SC*, and Clark LA* (2012). Genome-wide association mapping and identification of candidate genes for rumpless and ear-tufted traits of the Araucana chicken. PLoS ONE 7(7): e40974. [PubMed abstract]


Clark LA and Cox ML (2012). Current status of genetic studies of exocrine pancreatic insufficiency in dogs. Topics in Companion Animal Medicine 27 (3): 109-112. [PubMed abstract] 


Tsai KL, Noorai RE, Starr-Moss AN, Quignon P, Rinz CJ, Ostrander EA, Steiner JM, Murphy KE, and Clark LA (2012). Genome-wide association studies for multiple diseases of the German Shepherd dog. Mammalian Genome 23: 203-211. [PubMed abstract] 


Gill JL, Tsai KL, Krey C, Noorai RE, Vanbellinghen JF, Garosl LS, Shelton GD, Clark LA*, and Harvey RJ* (2012). A canine BCAN microdeletion associated with episodic falling syndrome. Neurobiology of Disease 45 (1): 130-136. [PubMed abstract]


Clark LA, Tsai KL, Starr AN, Nowend KL, and Murphy KE  (2011). A missense mutation in the 20S proteasome B2 subunit of Great Danes having harlequin coat patterning. Genomics 97: 244-248. [PubMed abstract]