Congenital Myasthenic Syndrome (CMS)
Congenital Myasthenic Syndrome (CMS) is a neuromuscular disorder that affects Jack Russell terriers. CMS is inherited in an autosomal recessive fashion and caused by a single nucleotide change in the gene CHRNE. Heterozygous carriers of the mutation do not exhibit any clinical signs of the disorder. A genetic test to identify carriers is available. For information about genetic testing please email Dr. Clark ([email protected]).