Congenital Myasthenic Syndrome (CMS)
Congenital Myasthenic Syndrome (CMS) is a neuromuscular disorder that affects Labrador retrievers. CMS is inherited in an autosomal recessive fashion and caused by a single nucleotide change in the gene COLQ. Heterozygous carriers of the mutation do not exhibit any clinical signs of the disorder. A genetic test to identify carriers is available. For information about genetic testing please email Dr. Clark ([email protected]).
Click here to read the article describing CMS in Labrador retrievers and the discovery of the causative mutation.